Tryptophan

Tryptophan

SCHEMBL1946948

N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.[N].c1ccc2[nH]ccc2c1

nearest known ligand 0.78

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.78
▸ KDM4E B2RXH2 3/20 0.78
▸ MAPT P10636 3/20 0.78
▸ LMNA P02545 2/20 0.78
▸ TSHR P16473 2/20 0.78
▸ BLM P54132 2/20 0.78
▸ PMP22 Q01453 2/20 0.78
▸ MEN1 O00255 2/20 0.78
▸ MPO P05164 1/20 0.78
▸ HIF1A Q16665 1/20 0.78
▸ SMN1; SMN2 Q16637 1/20 0.56
▸ APAF1 O14727 1/20 0.55
▸ POLB P06746 1/20 0.55
▸ RECQL P46063 1/20 0.55
▸ L3MBTL1 Q9Y468 1/20 0.55
▸ HTR1A P08908 2/20 0.55
▸ HTR2A P28223 2/20 0.55
▸ HTR2C P28335 2/20 0.55
▸ SLC6A4 P31645 2/20 0.55
▸ HTR7 P34969 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL1981758 0.99 KMT2A (0.80) KMT2AKDM4EMAPTLMNATSHR
D-Tryptophan SCHEMBL16390702 0.99 KMT2A (0.80) KMT2AKDM4EMAPTLMNATSHR
Dl-Tryptophan SCHEMBL1981755 0.99 KMT2A (0.80) KMT2AKDM4EMAPTLMNATSHR
Dl-Tryptophan SCHEMBL21179136 0.98 KMT2A (0.78) KMT2AKDM4EMAPTLMNATSHR
Dl-Tryptophan SCHEMBL28996529 0.92 KDM4E (0.70) KMT2AKDM4EMAPTLMNATSHR
Dl-Tryptophan SCHEMBL10481608 0.90 KDM4E (0.67) KMT2AKDM4EMAPTLMNATSHR
Tryptophan SCHEMBL22089471 0.90 KDM4E (0.67) KMT2AKDM4EMAPTLMNATSHR
Tryptophan SCHEMBL10481609 0.90 KDM4E (0.67) KMT2AKDM4EMAPTLMNATSHR
Tryptophan SCHEMBL29733043 0.90 KMT2A (0.97) KMT2AKDM4EMAPTLMNATSHR
Dl-Tryptophan SCHEMBL25388544 0.89 KMT2A (0.65) KMT2AKDM4EMAPTLMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10696954-B2 Hybrid peroxidases with enhanced activity and stability THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-06-30 — — US disclosed
EP-2435060-B1 OCCIDIOFUNGIN, A UNIQUE ANTIFUNGAL GLYCOPEPTIDE PRODUCED BY A STRAIN OF BURKHOLDERIA CONTAMINANS UNIV MISSISSIPPI STATE (US) 2019-08-28 — — EP disclosed
US-20190241875-A1 HYBRID PEROXIDASES WITH ENHANCED ACTIVITY AND STABILITY UNITED STATES DEPARTMENT OF ENERGY 2019-08-08 — — US disclosed
US-10092622-B2 Occidiofungin, a unique antifungal glycopeptide produced by a strain of Burkholderia contaminans MISSISSIPPI STATE UNIVERSITY (US) 2018-10-09 — — US disclosed
US-20180085452-A1 MATRIX-EMBEDDED TOLERANCE-PROMOTING ADJUVANTS FOR SUBCUTANEOUS IMMUNOTHERAPY LUXEMBOURG INSTITUTE OF HEALTH (LU) 2018-03-29 — — US disclosed
CN-107827956-A A kind of active ring octapeptide Reniochalistatin E and the like synthetic method 暨南大学 2018-03-23 — — CN disclosed
EP-3251662-A1 MATRIX-EMBEDDED TOLERANCE-PROMOTION ADJUVANTS FOR SUBCUTANEOUS IMMUNOTHERAPY Tolerogenics S.à.r.l. (LU) 2017-12-06 — — EP disclosed
US-20160338955-A1 ANTIGEN-SPECIFIC IMMUNOTHERAPY USING TOLERIZING LIPOSOMES PLS-DESIGN GMBH (DE) 2016-11-24 — — US disclosed
EP-3095440-A1 ANTIGEN-SPECIFIC IMMUNOTHERAPY USING TOLERIZING LIPOSOMES PLS-Design GmbH (DE) 2016-11-23 — — EP disclosed
US-20160271257-A1 Low Molecular Weight Immune-Modulators As Adjuvants for Specific Immunotherapy PLS DESIGN GMBH (DE) 2016-09-22 — — US disclosed
US-20160008423-A1 Occidiofungin, a unique antifungal glycopeptide produced by a strain of Burkholderia contaminans MISSISSIPPI STATE UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2016-01-14 — — US disclosed
WO-2014198420-A1 LOW MOLECULAR WEIGHT IMMUNE-MODULATORS AS ADJUVANTS FOR SPECIFIC IMMUNOTHERAPY PLS-DESIGN GMBH (DE) 2014-12-18 — — WO disclosed
EP-2813242-A1 Low molecular weight immune-modulators as adjuvants for specific immunotherapy PLS-Design GmbH (DE) 2014-12-17 — — EP disclosed
CN-102448481-A Occidiofungin, a unique antifungal glycopeptide produced by a strain of burkholderia contaminans UNIV MISSISSIPPI STATE 2012-05-09 — — CN disclosed
EP-2435060-A1 OCCIDIOFUNGIN, A UNIQUE ANTIFUNGAL GLYCOPEPTIDE PRODUCED BY A STRAIN OF BURKHOLDERIA CONTAMINANS Mississippi State University (US) 2012-04-04 — — EP disclosed
US-20110136729-A1 Occidiofungin, a unique antifungal glycopeptide produced by a strain of burkholderia contaminans MISSISSIPPI STATE UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION 2011-06-09 — — US disclosed
WO-2010138173-A1 OCCIDIOFUNGIN, A UNIQUE ANTIFUNGAL GLYCOPEPTIDE PRODUCED BY A STRAIN OF BURKHOLDERIA CONTAMINANS MISSISSIPPI STATE UNIVERSITY (US) 2010-12-02 — — WO disclosed
US-6465432-B1 PROTEOLYTIC CLEAVAGE OF PROTEINS; FOOD SUPPLEMENTS OF AMINO ACID SEQ ID NO:1-5 KRAFT FOOD HOLDINGS, INC. 2002-10-15 — — US disclosed
EP-1188767-A1 Isolated antioxidant peptides from casein and methods for preparing, isolating and identifying antioxidant peptides KRAFT FOODS HOLDINGS, INC. (US) 2002-03-20 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110136729-A1 Occidiofungin, a unique antifungal glycopeptide produced by a strain of burkholderia contaminans OGA, ENGASE, ST3GAL3 KMT2A 4535/4885KDM4E 4339/4885MAPT 4604/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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