Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | BLM | P54132 | 2/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | MPO | P05164 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL10481608 | 1.00 | KDM4E (0.67) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL1981758 | 0.91 | KMT2A (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| D-Tryptophan SCHEMBL16390702 | 0.91 | KMT2A (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL7103661 | 0.91 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL1981755 | 0.91 | KMT2A (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL1946948 | 0.90 | KMT2A (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL21179136 | 0.90 | KMT2A (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL3225365 | 0.87 | KMT2A (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL3225377 | 0.87 | KMT2A (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27533141 | 0.87 | KMT2A (0.89) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0217862-A4 | -i(IN VITRO) SYNTHESIS OF L-TRYPTOPHAN. | GENEX CORP (US) | 1989-12-28 | — | — | EP | disclosed |
| EP-0217862-A1 | $i(IN VITRO) SYNTHESIS OF L-TRYPTOPHAN | GENEX CORPORATION (US) | 1987-04-15 | — | — | EP | disclosed |
| WO-1986005515-A1 | IN VITRO SYNTHESIS OF L-TRYPTOPHAN | GENEX CORPORATION (US) | 1986-09-25 | — | — | WO | disclosed |