Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | CASP1 | P29466 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17066273 | 0.81 | CYP1A2 (0.64) | CYP1A2MAPTALDH1A1KMT2ARAB9A | |
| Acridone SCHEMBL243819 | 0.80 | KDM4E (0.56) | CYP1A2MAPTALDH1A1KMT2ARAB9A | |
| SCHEMBL28027778 | 0.79 | ESR1 (0.50) | CYP1A2MAPTALDH1A1KMT2ARAB9A | |
| SCHEMBL8886826 | 0.78 | CDK4 (0.50) | MAPTALDH1A1KMT2ARAB9AGAA | |
| Acridone SCHEMBL5719993 | 0.78 | KDM4E (0.54) | CYP1A2MAPTALDH1A1KMT2ARAB9A | |
| Acridone SCHEMBL10800711 | 0.78 | KDM4E (0.54) | CYP1A2MAPTALDH1A1KMT2ARAB9A | |
| Acridone SCHEMBL345058 | 0.78 | ALDH1A1 (0.54) | CYP1A2MAPTALDH1A1KMT2ARAB9A | |
| Acridone SCHEMBL27574706 | 0.78 | KDM4E (0.54) | CYP1A2MAPTALDH1A1KMT2ARAB9A | |
| Acridone SCHEMBL429571 | 0.78 | ALDH1A1 (0.54) | CYP1A2MAPTALDH1A1KMT2ARAB9A | |
| SCHEMBL14917525 | 0.78 | DHODH (0.53) | CYP1A2MAPTALDH1A1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10479787-B2 | Process for preparation of tetrabenazine and deutetrabenazine | LUPIN LIMITED (IN) | 2019-11-19 | — | — | US | claimed |
| US-20190135803-A1 | NOVEL PROCESS FOR PREPARATION OF TETRABENAZINE AND DEUTETRABENAZINE | LUPIN LIMITED (IN) | 2019-05-09 | — | — | US | claimed |
| US-20210230155-A1 | PROCESS FOR PREPARATION OF ((3R,11BR)-1,3,4,6,7,11B-HEXAHYDRO-9,10-DI(METHOXY-D3)-3-(2-METHYLPROPYL)-2H-BENZO[A]QUINOLIZIN-2-ONE | HETERO LABS LIMITED (IN) | 2021-07-29 | — | — | US | disclosed |
| EP-3784238-A1 | PROCESS FOR PREPARATION OF ((3R,11BR)-1,3,4,6,7,11B-HEXAHYDRO-9,10-DI(METHOXY-D)-3-(2-METHYLPROPYL)-2H-BENZO[A]QUINOLIZIN-2-ONE | Hetero Labs Ltd. (IN) | 2021-03-03 | — | — | EP | disclosed |
| US-10479787-B2 | Process for preparation of tetrabenazine and deutetrabenazine | LUPIN LIMITED (IN) | 2019-11-19 | — | — | US | disclosed |
| US-10479787-B2 | Process for preparation of tetrabenazine and deutetrabenazine | LUPIN LIMITED (IN) | 2019-11-19 | — | — | US | disclosed |
| US-20190135803-A1 | NOVEL PROCESS FOR PREPARATION OF TETRABENAZINE AND DEUTETRABENAZINE | LUPIN LIMITED (IN) | 2019-05-09 | — | — | US | disclosed |
| US-20190135803-A1 | NOVEL PROCESS FOR PREPARATION OF TETRABENAZINE AND DEUTETRABENAZINE | LUPIN LIMITED (IN) | 2019-05-09 | — | — | US | disclosed |
| WO-2017182916-A1 | NOVEL PROCESS FOR PREPARATION OF TETRABENAZINE AND DEUTETRABENAZINE | LUPIN LIMITED (IN) | 2017-10-26 | — | — | WO | disclosed |
| WO-2017182916-A1 | NOVEL PROCESS FOR PREPARATION OF TETRABENAZINE AND DEUTETRABENAZINE | LUPIN LIMITED (IN) | 2017-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190135803-A1 | NOVEL PROCESS FOR PREPARATION OF TETRABENAZINE AND DEUTETRABENAZINE | KAT5, KAT2A, KAT2B | CYP1A2 113/4885MAPT 1647/4885ALDH1A1 627/4885 |
| US-20210230155-A1 | PROCESS FOR PREPARATION OF ((3R,11BR)-1,3,4,6,7,11B-HEXAHYDRO-9,10-DI(METHOXY-D3)-3-(2-METHYLPROPYL)-2H-BENZO[A]QUINOLIZIN-2-ONE | CYP4B1, CYP1B1, UGT1A3 | CYP1A2 21/4885MAPT 3133/4885ALDH1A1 482/4885 |
| US-10479787-B2 | Process for preparation of tetrabenazine and deutetrabenazine | KAT5, KAT2A, KAT2B | CYP1A2 142/4885MAPT 1505/4885ALDH1A1 659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.