Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | ERN1 | O75460 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.45 |
| ▸ | TUBB | P07437 | 3/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28546991 | 0.78 | PDGFRB (0.57) | PDGFRBPDGFRAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL12312144 | 0.78 | PDGFRB (0.57) | PDGFRBPDGFRAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7562427 | 0.78 | ALDH1A1 (0.61) | PDGFRBPDGFRAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1316529 | 0.78 | NR4A2 (0.53) | PDGFRBPDGFRAERN1MAPTTDP1 | |
| SCHEMBL2751688 | 0.77 | PDE4A (0.53) | PDGFRBPDGFRAERN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27989353 | 0.77 | ERN1 (0.52) | ERN1ALDH1A1MAPTHTTTDP1 | |
| SCHEMBL2650245 | 0.77 | ERN1 (0.52) | ERN1ALDH1A1SMN1; SMN2MAPTHTT | |
| SCHEMBL12312167 | 0.76 | KMT2A (0.58) | PDGFRBPDGFRAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19475454 | 0.75 | ERN1 (0.50) | PDGFRBPDGFRAERN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14713554 | 0.75 | ALDH1A1 (0.62) | PDGFRBPDGFRAERN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190119284-A1 | ErbB Inhibitors and Uses Thereof | THE SCRIPPS RESEARCH INSTITUTE | 2019-04-25 | — | — | US | disclosed |
| US-20190119284-A1 | ErbB Inhibitors and Uses Thereof | THE SCRIPPS RESEARCH INSTITUTE | 2019-04-25 | — | — | US | disclosed |
| WO-2017184775-A1 | ERBB INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-26 | — | — | WO | disclosed |
| WO-2017184775-A1 | ERBB INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190119284-A1 | ErbB Inhibitors and Uses Thereof | ERBB3, ERBB2, EGFR | PDGFRB 16/4885PDGFRA 28/4885ERN1 1245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.