Guanidine — predicted protein targets

Known targets — ChEMBL curated mechanism

KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2

The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	ASGR1	P07306	4/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL16008570	0.91	ASGR1 (0.38)	ASGR1
SCHEMBL20078030	0.91	ASGR1 (0.38)	ASGR1
SCHEMBL16691272	0.91	ASGR1 (0.38)	ASGR1
SCHEMBL7109122	0.91	ASGR1 (0.38)	ASGR1
SCHEMBL24256008	0.80	ASGR1 (0.45)	ASGR1
Uracil SCHEMBL7108401	0.71	CRBN (0.44)	—
Adenine SCHEMBL19474976	0.71	HSP90B1 (0.33)	—
Thymine SCHEMBL19474978	0.70	ATAD2 (0.46)	ASGR1
Thymine SCHEMBL7107663	0.70	ATAD2 (0.46)	ASGR1
SCHEMBL24268197	0.67	ASGR1 (0.37)	ASGR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017184082-A1	A LYMPHOCYTE PERMEATING CHIMERIC OLIGONUCLEOTIDE, METHODS AND USES THEREOF	NANYANG TECHNOLOGICAL UNIVERSITY (SG)	2017-10-26	—	—	WO	disclosed