Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM4B | O94953 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | JMJD6 | Q6NYC1 | 9/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16035670 | 0.84 | KEAP1 (0.46) | KEAP1KDM4AKDM4BKDM5BJMJD6 | |
| SCHEMBL20912233 | 0.81 | KDM4A (0.46) | KEAP1KDM4AKDM4BKDM5BJMJD6 | |
| SCHEMBL22230356 | 0.78 | KEAP1 (0.50) | KEAP1KDM4AKDM4BKDM5BJMJD6 | |
| SCHEMBL30509529 | 0.75 | KMT2A (0.46) | KEAP1KDM4AKDM4BKDM5BJMJD6 | |
| SCHEMBL30211937 | 0.74 | KEAP1 (0.46) | KEAP1KDM4AKDM4BKDM5BJMJD6 | |
| SCHEMBL18448976 | 0.69 | KDM4A (0.44) | KEAP1KDM4AKDM4BKDM5BJMJD6 | |
| SCHEMBL26966622 | 0.69 | KDM4A (0.44) | KEAP1KDM4AKDM4BKDM5BJMJD6 | |
| SCHEMBL19480885 | 0.68 | KEAP1 (0.43) | KEAP1JMJD6KMT2ASCN4AADORA2A | |
| SCHEMBL18157906 | 0.67 | KMT2A (0.64) | KEAP1KDM4AKDM4BKDM5BJMJD6 | |
| SCHEMBL30989082 | 0.67 | KDM5B (0.43) | KEAP1KDM4AKDM4BKDM5BJMJD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017178344-A1 | NOVEL N-[(HETEROARYLOXY)PROPANYL]HETEROARYL CARBOXAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-19 | — | — | WO | disclosed |