Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.60 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 5/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1948364 | 0.90 | ESR2 (0.60) | ESR2HSD17B3NR1H2NAMPTTMPRSS2 | |
| SCHEMBL17797522 | 0.89 | ESR2 (0.56) | ESR2NR1H2NAMPTTMPRSS2NPC1 | |
| SCHEMBL2639196 | 0.84 | HSD17B3 (0.68) | HSD17B3TMPRSS2HCRTR2HCRTR1TMEM97 | |
| SCHEMBL25074088 | 0.84 | ESR2 (0.61) | ESR2NR1H2NAMPTNPC1RAB9A | |
| SCHEMBL6882871 | 0.84 | RYR2 (0.55) | HSD17B3NAMPTACHEMAPK1 | |
| SCHEMBL2181843 | 0.84 | ESR2 (0.58) | ESR2NR1H2NAMPTTMPRSS2TMEM97 | |
| SCHEMBL20536418 | 0.83 | HSD17B3 (0.57) | HSD17B3NAMPTTMPRSS2HCRTR2HCRTR1 | |
| SCHEMBL1188540 | 0.83 | ESR2 (0.62) | ESR2NR1H2NAMPTTMPRSS2NPC1 | |
| SCHEMBL31173434 | 0.83 | ESR2 (0.62) | ESR2NR1H2NAMPTNPC1RAB9A | |
| SCHEMBL3007628 | 0.81 | ESR2 (0.53) | ESR2NR1H2NAMPTTMPRSS2HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438055-B1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | JAPAN TOBACCO INC (JP) | 2018-10-24 | — | — | EP | disclosed |
| US-8426442-B2 | Compounds | XENTION LTD (GB) | 2013-04-23 | — | — | US | disclosed |
| EP-2438055-A1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2012-04-11 | — | — | EP | disclosed |
| US-20110136860-A1 | Compounds | XENTION LTD. (GB) | 2011-06-09 | — | — | US | disclosed |
| WO-2010139967-A1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136860-A1 | Compounds | NR3C2, NR5A1, NR0B2 | ESR2 394/4885HSD17B3 225/4885NR1H2 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.