Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BCAT1 | P54687 | 2/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17902701 | 0.89 | KMT2A (0.50) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL19077940 | 0.86 | LMNA (0.50) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL17902684 | 0.85 | KMT2A (0.51) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL17902702 | 0.84 | MAPT (0.59) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL17898591 | 0.82 | MAPT (0.55) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL17898596 | 0.82 | MAPT (0.52) | MAPTLMNAALDH1A1KMT2ANPSR1 | |
| SCHEMBL17902686 | 0.81 | KMT2A (0.53) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL19077934 | 0.81 | NPC1 (0.55) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL17902689 | 0.79 | MAPT (0.50) | MAPTLMNAALDH1A1GAANPSR1 | |
| SCHEMBL13005791 | 0.78 | MAPT (0.55) | MAPTALDH1A1KMT2ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9795586-B2 | HNF4-α antagonist and use thereof | NATIONAL CANCER CENTER (KR) | 2017-10-24 | — | — | US | disclosed |