Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30776670 | 0.88 | ALDH1A1 (0.46) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL3361536 | 0.88 | ALDH1A1 (0.46) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL24437403 | 0.88 | ALDH1A1 (0.46) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7099805 | 0.85 | ALDH1A1 (0.50) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL16865875 | 0.85 | ALDH1A1 (0.50) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL6423584 | 0.85 | ALDH1A1 (0.50) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL16865878 | 0.85 | ALDH1A1 (0.50) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL11982806 | 0.81 | ALDH1A1 (0.47) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL11982739 | 0.81 | ALDH1A1 (0.47) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL2999171 | 0.79 | TP53 (0.47) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017179065-A1 | IMPROVED PROCESS FOR THE PREPARATION OF APREMILAST | DAVULURI RAMAMOHAN RAO (IN) | 2017-10-19 | — | — | WO | disclosed |