Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | S100B | P04271 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15358736 | 0.87 | ALDH1A1 (0.53) | SIRT6ALDH1A1LMNACYP3A4TDP1 | |
| SCHEMBL29446146 | 0.81 | MAPT (0.63) | SIRT6ALDH1A1CYP3A4TDP1TSHR | |
| SCHEMBL438444 | 0.81 | MAPT (0.63) | SIRT6ALDH1A1CYP3A4TDP1TSHR | |
| SCHEMBL2974453 | 0.81 | ALDH1A1 (0.59) | ALDH1A1LMNACYP3A4TDP1TSHR | |
| SCHEMBL11291219 | 0.81 | ALDH1A1 (0.43) | SIRT6ALDH1A1LMNACYP3A4TDP1 | |
| SCHEMBL24900714 | 0.80 | ALDH1A1 (0.46) | SIRT6ALDH1A1LMNACYP3A4TDP1 | |
| Hydrochloric Acid SCHEMBL3504109 | 0.80 | MAPT (0.61) | SIRT6ALDH1A1CYP3A4TDP1TSHR | |
| SCHEMBL2821837 | 0.80 | MAPT (0.48) | ALDH1A1LMNACYP3A4TDP1TSHR | |
| SCHEMBL10128598 | 0.80 | ALDH1A1 (0.59) | ALDH1A1LMNACYP3A4TDP1TSHR | |
| SCHEMBL30340649 | 0.80 | ALDH1A1 (0.59) | ALDH1A1LMNACYP3A4TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3293183-B1 | INHIBITOR COMPOUNDS | CANCER RESEARCH TECH LTD (GB) | 2019-07-24 | — | — | EP | disclosed |
| EP-3293183-A1 | INHIBITOR COMPOUNDS | Cancer Research Technology Ltd. (GB) | 2018-03-14 | — | — | EP | disclosed |
| EP-2892889-B1 | INHIBITOR COMPOUNDS | CANCER RES TECH LTD (GB) | 2017-10-18 | — | — | EP | disclosed |