Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.77 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.77 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.60 |
| ▸ | TGFB1 | P01137 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19492208 | 0.92 | TGFBR1 (0.65) | TGFBR1MAPK14RIPK2TGFB1KDR | |
| SCHEMBL247412 | 0.88 | TGFBR1 (1.00) | TGFBR1MAPK14RIPK2TGFB1KDR | |
| SCHEMBL250018 | 0.82 | TGFBR1 (1.00) | TGFBR1MAPK14 | |
| SCHEMBL249307 | 0.80 | TGFBR1 (0.82) | TGFBR1MAPK14 | |
| SCHEMBL19492211 | 0.80 | TGFBR1 (0.81) | TGFBR1MAPK14 | |
| SCHEMBL248193 | 0.79 | TGFBR1 (1.00) | TGFBR1MAPK14RIPK2TGFB1KDR | |
| SCHEMBL250379 | 0.79 | TGFBR1 (1.00) | TGFBR1MAPK14 | |
| SCHEMBL19492123 | 0.79 | TGFBR1 (0.83) | TGFBR1MAPK14RIPK2TGFB1KDR | |
| SCHEMBL250104 | 0.79 | TGFBR1 (1.00) | TGFBR1MAPK14 | |
| SCHEMBL19492283 | 0.78 | TGFBR1 (0.73) | TGFBR1MAPK14RIPK2TGFB1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2947081-B1 | 2-Pyridyl substituted imidazoles as therapeutic Alk5 and/or Alk4 inhibitors | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUND (KR) | 2017-10-18 | — | — | EP | disclosed |