Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | AIP | O00170 | 1/20 | 0.41 |
| ▸ | SGTA | O43765 | 1/20 | 0.41 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.41 |
| ▸ | STIP1 | P31948 | 1/20 | 0.41 |
| ▸ | PPP5C | P53041 | 1/20 | 0.41 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.41 |
| ▸ | PPID | Q08752 | 1/20 | 0.41 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.41 |
| ▸ | FKBP8 | Q14318 | 1/20 | 0.41 |
| ▸ | TOMM34 | Q15785 | 1/20 | 0.41 |
| ▸ | DNAJC7 | Q99615 | 1/20 | 0.41 |
| ▸ | AIPL1 | Q9NZN9 | 1/20 | 0.41 |
| ▸ | STUB1 | Q9UNE7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16246427 | 0.76 | KMT2A (0.49) | KMT2AKDM4EMEN1CYP1A2CYP2C19 | |
| SCHEMBL11324603 | 0.76 | AIP (0.66) | KMT2AKDM4EMEN1CYP1A2CYP2C19 | |
| SCHEMBL16246353 | 0.72 | KMT2A (0.44) | KMT2AKDM4EMEN1CYP1A2CYP2C19 | |
| SCHEMBL11641915 | 0.72 | KMT2A (0.44) | KMT2AKDM4EMEN1CYP1A2CYP2C19 | |
| SCHEMBL19494287 | 0.70 | KMT2A (0.46) | KMT2AKDM4EMEN1CYP1A2CYP2C19 | |
| SCHEMBL8290398 | 0.64 | ALDH1A1 (0.77) | KMT2AKDM4EMEN1CYP1A2CYP2C19 | |
| SCHEMBL16246479 | 0.64 | ALDH1A1 (0.49) | KMT2AKDM4EMEN1CYP1A2CYP2C19 | |
| SCHEMBL8277600 | 0.64 | AIP (0.62) | KMT2AKDM4EMEN1CYP1A2CYP2C19 | |
| SCHEMBL16246338 | 0.63 | ALDH1A1 (0.48) | KMT2AKDM4EMEN1CYP1A2CYP2C19 | |
| SCHEMBL1926572 | 0.62 | MAPT (0.48) | KMT2AKDM4EMEN1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |