Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.44 |
| ▸ | IKBKB | O14920 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494741 | 0.81 | CFTR (0.49) | CFTRIKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL19494932 | 0.81 | IKBKB (0.43) | CFTRIKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL16263785 | 0.80 | CHEK1 (0.50) | CFTRIKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL19494743 | 0.79 | CHEK1 (0.39) | CFTRIKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL19494466 | 0.78 | CHEK1 (0.48) | CFTRMEN1KMT2ACHEK1MAPK8 | |
| SCHEMBL16263935 | 0.78 | JAK2 (0.42) | CFTRIKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL16263917 | 0.78 | CFTR (0.73) | CFTRIKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL19494396 | 0.77 | CFTR (0.43) | CFTRIKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL19494662 | 0.75 | TYK2 (0.44) | CFTRIKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL19494685 | 0.74 | CFTR (0.49) | CFTRIKBKBJAK2MEN1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |