Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.43 |
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 4/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494507 | 0.81 | IKBKB (0.40) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL19494397 | 0.81 | CFTR (0.44) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL19494741 | 0.81 | CFTR (0.49) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL19494474 | 0.80 | NNMT (0.37) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL16263935 | 0.79 | JAK2 (0.42) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL19494366 | 0.79 | JAK2 (0.55) | JAK2 | |
| SCHEMBL19494743 | 0.76 | CHEK1 (0.39) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL19494662 | 0.76 | TYK2 (0.44) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL16263785 | 0.72 | CHEK1 (0.50) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL19494736 | 0.72 | JAK2 (0.32) | IKBKBJAK2MEN1KMT2ACFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |