Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494498 | 0.91 | CFTR (0.40) | MAPTALDH1A1HSD17B10USP2ALOX15 | |
| SCHEMBL19494701 | 0.81 | IKBKE (0.40) | MAPTALDH1A1HSD17B10USP2ALOX15 | |
| SCHEMBL19494492 | 0.81 | ALDH1A1 (0.39) | MAPTALDH1A1HSD17B10USP2ALOX15 | |
| SCHEMBL19494640 | 0.80 | IRAK4 (0.43) | MAPTALDH1A1HSD17B10USP2ALOX15 | |
| SCHEMBL16263645 | 0.80 | CFTR (0.55) | MAPTALDH1A1HSD17B10USP2ALOX15 | |
| SCHEMBL19494684 | 0.78 | NPC1 (0.46) | MAPTALDH1A1HSD17B10USP2KDM4E | |
| SCHEMBL19494339 | 0.77 | MAPT (0.38) | MAPTALDH1A1HSD17B10USP2ALOX15 | |
| SCHEMBL19494588 | 0.77 | MAPT (0.47) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL16246391 | 0.77 | CFTR (0.56) | MAPTALDH1A1HSD17B10USP2ALOX15 | |
| SCHEMBL19494391 | 0.76 | IKBKB (0.34) | MAPTALDH1A1HSD17B10USP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |