Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16246257 | 0.86 | CFTR (0.52) | CFTRLMNAMAPTPOLBTP53 | |
| SCHEMBL28156782 | 0.80 | LMNA (0.42) | LMNAMAPTPOLBTP53KDM4E | |
| SCHEMBL19494890 | 0.75 | KDM4E (0.48) | LMNAMAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL16387398 | 0.74 | CFTR (0.52) | CFTRLMNAMAPTPOLBTP53 | |
| SCHEMBL16246540 | 0.74 | CFTR (0.52) | CFTRLMNAMAPTPOLBTP53 | |
| SCHEMBL16246408 | 0.74 | CFTR (0.68) | CFTRLMNAMAPTPOLBTP53 | |
| SCHEMBL16246482 | 0.73 | CFTR (0.50) | CFTRLMNAMAPTPOLBKDM4E | |
| SCHEMBL16263734 | 0.73 | CFTR (0.51) | CFTRLMNAMAPTPOLBTP53 | |
| SCHEMBL16246311 | 0.73 | CFTR (0.51) | CFTRLMNAMAPTPOLBTP53 | |
| SCHEMBL16246499 | 0.72 | CFTR (0.50) | CFTRLMNAMAPTPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |