Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 3/20 | 0.34 |
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16338254 | 0.80 | CFTR (0.53) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL19494633 | 0.79 | ALDH1A1 (0.33) | TBK1IKBKEALDH1A1MAPTKDM4E | |
| SCHEMBL18044891 | 0.67 | CFTR (0.39) | CFTRKCNH2CHEK1 | |
| SCHEMBL16338427 | 0.64 | CFTR (0.56) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL16246521 | 0.62 | KMT2A (0.57) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL16246308 | 0.62 | CFTR (0.53) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL16246489 | 0.62 | CFTR (0.52) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL6700332 | 0.61 | PIK3CA (0.45) | MAPTKDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL16246404 | 0.61 | TSHR (0.57) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL16246490 | 0.60 | CFTR (0.51) | ALDH1A1MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |