Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494611 | 0.83 | CFTR (0.45) | CFTRMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL16338203 | 0.75 | CFTR (0.54) | CFTRMAPK8MEN1ALDH1A1KMT2A | |
| SCHEMBL19494440 | 0.72 | MAPK1 (0.31) | MAPK1GFER | |
| SCHEMBL19494728 | 0.70 | CFTR (0.50) | CFTRMAPK8MEN1KMT2ACHEK1 | |
| SCHEMBL19494636 | 0.68 | CFTR (0.43) | CFTRMAPK8MEN1ALDH1A1KMT2A | |
| SCHEMBL19494313 | 0.68 | IKBKB (0.32) | MEN1ALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL19494401 | 0.68 | CFTR (0.46) | CFTRMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL16246534 | 0.67 | CFTR (0.51) | CFTRMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL16246527 | 0.66 | CFTR (0.58) | CFTRMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL19494695 | 0.66 | MAPK1 (0.41) | CFTRMEN1ALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |