Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494401 | 0.79 | CFTR (0.46) | MAPK1GFERHTTMAPTHPGD | |
| SCHEMBL19494686 | 0.75 | MAPK8 (0.49) | MAPTHPGDCHEK1KDM4EMEN1 | |
| SCHEMBL16338734 | 0.75 | CFTR (0.56) | MAPK1GFERMAPK10HTTMAPT | |
| SCHEMBL19494892 | 0.73 | MMP1 (0.41) | MAPK10HTTMAPTHPGDKDM4E | |
| SCHEMBL19494386 | 0.73 | CFTR (0.39) | MAPK1GFERMAPK10MAPTHPGD | |
| SCHEMBL19494611 | 0.70 | CFTR (0.45) | MAPTCHEK1KDM4EMEN1KMT2A | |
| SCHEMBL19494313 | 0.68 | IKBKB (0.32) | MAPTKDM4EMEN1KMT2AUSP2 | |
| SCHEMBL19494440 | 0.68 | MAPK1 (0.31) | MAPK1GFER | |
| SCHEMBL19494647 | 0.66 | CFTR (0.41) | MAPK1GFERHPGDCHEK1KDM4E | |
| SCHEMBL19494312 | 0.66 | MEN1 (0.32) | MAPTKDM4EMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |