Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 5/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 2/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16263850 | 0.80 | CFTR (0.53) | CFTRCHEK1MEN1ALDH1A1KMT2A | |
| SCHEMBL16246515 | 0.75 | CFTR (0.56) | CFTRCHEK1MEN1ALDH1A1KMT2A | |
| SCHEMBL19494685 | 0.71 | CFTR (0.49) | CFTRCHEK1MEN1ALDH1A1KMT2A | |
| SCHEMBL19494765 | 0.71 | CFTR (0.54) | CFTRMEN1ALDH1A1KMT2AMAPK1 | |
| SCHEMBL16263805 | 0.70 | CFTR (0.55) | CFTRCHEK1MEN1ALDH1A1KMT2A | |
| SCHEMBL19494946 | 0.69 | CFTR (0.51) | CFTRCHEK1MEN1ALDH1A1KMT2A | |
| SCHEMBL16263944 | 0.69 | CFTR (0.57) | CFTRCHEK1MEN1ALDH1A1KMT2A | |
| SCHEMBL16263780 | 0.69 | CFTR (0.45) | CFTRALDH1A1KMT2AHSD17B10IKBKB | |
| SCHEMBL19494388 | 0.69 | MEN1 (0.36) | CFTRCHEK1MEN1ALDH1A1KMT2A | |
| SCHEMBL19494373 | 0.68 | CFTR (0.48) | CFTRCHEK1MEN1KMT2AIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |