Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 2/20 | 0.33 |
| ▸ | CFTR | P13569 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494323 | 0.71 | CHEK1 (0.37) | MEN1KMT2ACHEK1KDM4EMAPT | |
| SCHEMBL19494932 | 0.69 | IKBKB (0.43) | MEN1KMT2ACFTRIKBKB | |
| SCHEMBL19494752 | 0.69 | CFTR (0.45) | MEN1KMT2ACHEK1GFERCFTR | |
| SCHEMBL19494507 | 0.68 | IKBKB (0.40) | MEN1KMT2ACFTRIKBKB | |
| SCHEMBL19494912 | 0.68 | CFTR (0.40) | MEN1KMT2AKDM4EMAPTNPSR1 | |
| SCHEMBL19494474 | 0.68 | NNMT (0.37) | MEN1KMT2AKDM4ECFTRALDH1A1 | |
| SCHEMBL19494633 | 0.67 | ALDH1A1 (0.33) | MEN1KMT2ACHEK1KDM4EMAPT | |
| SCHEMBL19494521 | 0.63 | CA2 (0.41) | MEN1KMT2ACHEK1KDM4EMAPT | |
| SCHEMBL19494736 | 0.63 | JAK2 (0.32) | MEN1KMT2AKDM4EMAPTNPSR1 | |
| SCHEMBL22652414 | 0.62 | NPSR1 (0.42) | MEN1KMT2AKDM4EMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |