Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | IKBKB | O14920 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494413 | 0.84 | IKBKB (0.46) | JAK2IKBKBMEN1KMT2AEIF2AK2 | |
| SCHEMBL19494924 | 0.83 | CHEK1 (0.51) | JAK2MAPK8 | |
| SCHEMBL19494396 | 0.80 | CFTR (0.43) | JAK2IKBKBMEN1KMT2AEIF2AK2 | |
| SCHEMBL19494442 | 0.79 | MEN1 (0.42) | JAK2IKBKBMEN1KMT2AEIF2AK2 | |
| SCHEMBL19494938 | 0.78 | MEN1 (0.41) | JAK2IKBKBMEN1KMT2AEIF2AK2 | |
| SCHEMBL19494459 | 0.77 | PIK3CB (0.41) | JAK2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL19494343 | 0.77 | IKBKB (0.39) | JAK2IKBKBMEN1KMT2AEIF2AK2 | |
| SCHEMBL19494470 | 0.77 | CHEK1 (0.38) | JAK2IKBKBMEN1KMT2AEIF2AK2 | |
| SCHEMBL19494512 | 0.76 | IKBKB (0.41) | JAK2IKBKBMEN1KMT2AEIF2AK2 | |
| SCHEMBL19494654 | 0.75 | NNMT (0.35) | JAK2IKBKBMEN1KMT2AEIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |