Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ACP3 | P15309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16427649 | 0.84 | SMN1; SMN2 (0.43) | KMT2AHSD17B2SMN1; SMN2MAPK1HSD11B1 | |
| SCHEMBL19499071 | 0.84 | SMN1; SMN2 (0.43) | KMT2AHSD17B2SMN1; SMN2MAPK1HSD11B1 | |
| SCHEMBL16428153 | 0.81 | KMT2A (0.42) | KMT2AHSD17B2SMN1; SMN2MAPK1HSD11B1 | |
| SCHEMBL19499465 | 0.80 | KMT2A (0.42) | KMT2AHSD17B2SMN1; SMN2MAPK1HSD11B1 | |
| SCHEMBL19947558 | 0.79 | SMN1; SMN2 (0.46) | KMT2AHSD17B2SMN1; SMN2MAPK1HSD11B1 | |
| SCHEMBL18645260 | 0.79 | SMN1; SMN2 (0.46) | KMT2AHSD17B2SMN1; SMN2MAPK1HSD11B1 | |
| SCHEMBL16428059 | 0.79 | SMN1; SMN2 (0.46) | KMT2AHSD17B2SMN1; SMN2MAPK1HSD11B1 | |
| SCHEMBL524313 | 0.79 | SMN1; SMN2 (0.46) | KMT2AHSD17B2SMN1; SMN2MAPK1HSD11B1 | |
| SCHEMBL16428060 | 0.79 | SMN1; SMN2 (0.46) | KMT2AHSD17B2SMN1; SMN2MAPK1HSD11B1 | |
| SCHEMBL17102255 | 0.79 | SMN1; SMN2 (0.46) | KMT2AHSD17B2SMN1; SMN2MAPK1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027601-B1 | SYK INHIBITORS | GILEAD SCIENCES INC (US) | 2017-10-25 | — | — | EP | disclosed |