Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.45 |
| ▸ | NPC1 | O15118 | 10/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6112679 | 0.81 | KDM4E (0.53) | RAB9ANPC1MAPTLMNAKLK5 | |
| SCHEMBL15544534 | 0.78 | KDM4E (0.46) | NPC1MAPTKLK5KDM4ESMN1; SMN2 | |
| SCHEMBL2857716 | 0.77 | NPC1 (0.46) | RAB9ANPC1MAPTKDM4EPOLB | |
| SCHEMBL6419529 | 0.75 | SMN1; SMN2 (0.47) | RAB9ANPC1MAPTLMNAKLK5 | |
| SCHEMBL2855682 | 0.73 | JAK2 (0.46) | MAPTLMNANFKB1KDM4ECYP1A2 | |
| SCHEMBL30444890 | 0.72 | KLK5 (0.57) | RAB9ANPC1MAPTLMNAKLK5 | |
| SCHEMBL2676424 | 0.72 | KLK5 (0.57) | RAB9ANPC1MAPTLMNAKLK5 | |
| SCHEMBL15532179 | 0.72 | KMT2A (0.52) | RAB9ANPC1MAPTLMNAKDM4E | |
| Hydrochloric Acid SCHEMBL5008243 | 0.71 | KLK5 (0.56) | RAB9ANPC1MAPTLMNAKLK5 | |
| SCHEMBL2857350 | 0.70 | DAPK3 (0.39) | RAB9ANPC1MAPTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3045456-B1 | BICYCLIC SUBSTITUTED URACILS AND THEIR USE | Bayer Pharma AG (DE) | 2017-10-25 | — | — | EP | disclosed |