SCHEMBL1950228

SCHEMBL1950228

CC(C)CC(C)C(=O)Nc1cc(NC(=O)C(C)CC(C)C)cc(NC(=O)C(C)CC(C)C)c1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 3/20 0.49
TSHR P16473 1/20 0.46
KMT2A Q03164 4/20 0.44
MEN1 O00255 2/20 0.44
HTT P42858 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
MME P08473 1/20 0.41
ACE P12821 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
AAK1 Q2M2I8 1/20 0.41
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA7 P43166 2/20 0.40
CA14 Q9ULX7 2/20 0.40
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1386042 0.82 MME (0.61) HSD17B10KMT2AMEN1HTTNPSR1
SCHEMBL16452816 0.82 MME (0.61) HSD17B10KMT2AMEN1HTTNPSR1
SCHEMBL26503435 0.81 MAPT (0.61) HSD17B10HTTSMN1; SMN2AAK1CA1
SCHEMBL1949535 0.81 HSD17B10 (0.69) HSD17B10TSHRKMT2AMEN1HTT
SCHEMBL26503486 0.80 KMT2A (0.55) KMT2AMEN1
SCHEMBL26503489 0.80 MEN1 (0.51) TSHRKMT2AMEN1CA1CA2
SCHEMBL26503494 0.80 MEN1 (0.63) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL26503441 0.79 SMN1; SMN2 (0.67) TSHRKMT2AMEN1HTTSMN1; SMN2
SCHEMBL26503469 0.78 MEN1 (0.54) HSD17B10KMT2AMEN1HTTSMN1; SMN2
SCHEMBL2623845 0.78 NPC1 (0.47) HSD17B10KMT2AMEN1MMEACE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1592738-B1 RESIN COMPOSITIONS CIBA HOLDING INC (CH) 2020-07-29 EP disclosed
US-9029446-B2 Clarified polypropylene articles with improved optical properties and/or increased temperature of crystallization BASF SE (DE) 2015-05-12 US disclosed
EP-2510047-B1 CLARIFIED POLYPROPYLENE ARTICLES WITH IMPROVED OPTICAL PROPERTIES AND/OR INCREASED TEMPERATURE OF CRYSTALLIZATION BASF SE (DE) 2014-11-05 EP disclosed
US-8415416-B2 Electret materials BASF SE (DE) 2013-04-09 US disclosed
US-20130012091-A1 Electret Materials BASF SE (DE) 2013-01-10 US disclosed
US-20120184170-A1 Electret Materials CHIN HUI (US) 2012-07-19 US disclosed
US-20110230109-A1 Electret Materials CHIN HUI 2011-09-22 US disclosed
US-20110136950-A1 Clarified Polypropylene Articles with Improved Optical Properties and/or increased temperature of Crystallization BASF SE (DE) 2011-06-09 US disclosed
US-7790793-B2 Amide nucleating agent compositions CIBA SPECIALTY CHEM. CORP. (US) 2010-09-07 US disclosed
US-20080249269-A1 Electret materials CIBA CORP. 2008-10-09 US disclosed
US-20070149663-A1 Resin compositions CIBA SPECIALTY CHEMICALS CORP. 2007-06-28 US disclosed