Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 16/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 16/20 | 0.56 |
| ▸ | BAD | Q92934 | 4/20 | 0.56 |
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.56 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | ASPH | Q12797 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19503603 | 0.96 | BCL2 (0.56) | BCL2BCL2L1BADBCL2L2BCL2L11 | |
| SCHEMBL19503725 | 0.96 | BCL2 (0.62) | BCL2BCL2L1BADBCL2L2BCL2L11 | |
| SCHEMBL22295609 | 0.86 | BCL2L1 (0.76) | BCL2BCL2L1BADBCL2L2BCL2L11 | |
| SCHEMBL19014640 | 0.86 | BCL2 (0.61) | BCL2BCL2L1BADBCL2L2BCL2L11 | |
| SCHEMBL22295589 | 0.85 | BCL2 (0.62) | BCL2BCL2L1BADBCL2L2BCL2L11 | |
| SCHEMBL19014638 | 0.79 | BCL2 (0.67) | BCL2BCL2L1BADBCL2L2BCL2L11 | |
| SCHEMBL29077589 | 0.77 | BCL2 (0.79) | BCL2BCL2L1BADBCL2L2BCL2L11 | |
| SCHEMBL19244593 | 0.77 | BCL2 (0.76) | BCL2BCL2L1BADBCL2L2BCL2L11 | |
| SCHEMBL29321403 | 0.77 | BCL2L1 (0.62) | BCL2BCL2L1BADBCL2L2BCL2L11 | |
| SCHEMBL19014717 | 0.77 | BCL2L1 (0.69) | BCL2BCL2L1BADBCL2L2BCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184995-A1 | COMPOUNDS THAT INDUCE DEGRADATION OF ANTI-APOPTOTIC BCL-2 FAMILY PROTEINS AND THE USES THEREOF | BIOVENTURES, LLC (US) | 2017-10-26 | — | — | WO | disclosed |