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SCHEMBL19503617

SCHEMBL19503617

C=C/C=C(\C)SC[C@@H](CCN(C)CC)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F

nearest known ligand 0.70

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ BCL2L1 Q07817 17/20 0.70
▸ BCL2 P10415 17/20 0.69
▸ BCL2L2 Q92843 3/20 0.69
▸ BAD Q92934 3/20 0.69
▸ BCL2L11 O43521 1/20 0.69
▸ CYP2C9 P11712 1/20 0.69
▸ MCL1 Q07820 1/20 0.69
▸ ASPH Q12797 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19503615 0.97 BCL2L1 (0.69) BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL20992957 0.91 BCL2L1 (0.83) BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL19014626 0.87 BCL2L1 (0.82) BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL19014637 0.87 BCL2L1 (0.76) BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL19145094 0.86 BCL2L1 (0.84) BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL2023846 0.86 BCL2L1 (0.84) BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL24985389 0.86 BCL2 (0.86) BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL1628701 0.86 BCL2 (0.86) BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL1567618 0.86 BCL2L1 (0.86) BCL2L1BCL2BCL2L2BADBCL2L11
SCHEMBL21179167 0.85 BCL2L1 (0.84) BCL2L1BCL2BCL2L2BADBCL2L11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017184995-A1 COMPOUNDS THAT INDUCE DEGRADATION OF ANTI-APOPTOTIC BCL-2 FAMILY PROTEINS AND THE USES THEREOF BIOVENTURES, LLC (US) 2017-10-26 — — WO disclosed
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