Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 11/20 | 0.37 |
| ▸ | EED | O75530 | 9/20 | 0.37 |
| ▸ | RBBP4 | Q09028 | 9/20 | 0.37 |
| ▸ | SUZ12 | Q15022 | 9/20 | 0.37 |
| ▸ | AEBP2 | Q6ZN18 | 9/20 | 0.37 |
| ▸ | EZH1 | Q92800 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19503760 | 0.79 | EZH2 (0.44) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19503879 | 0.76 | EZH2 (0.44) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18365032 | 0.69 | EZH2 (0.55) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18829914 | 0.69 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18829912 | 0.66 | EZH2 (0.60) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL29613562 | 0.66 | EZH2 (0.60) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL13276540 | 0.66 | EZH2 (0.60) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL13181167 | 0.65 | TACR1 (0.36) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL30499098 | 0.65 | EZH2 (0.59) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16935249 | 0.65 | EZH2 (0.49) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184999-A1 | EZH2 INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-10-26 | — | — | WO | disclosed |