Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 9/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | EED | O75530 | 8/20 | 0.41 |
| ▸ | RBBP4 | Q09028 | 8/20 | 0.41 |
| ▸ | SUZ12 | Q15022 | 8/20 | 0.41 |
| ▸ | AEBP2 | Q6ZN18 | 8/20 | 0.41 |
| ▸ | EZH1 | Q92800 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19503760 | 0.86 | EZH2 (0.44) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL29448162 | 0.78 | EZH2 (0.59) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL13276957 | 0.78 | EZH2 (0.59) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16935216 | 0.77 | EZH2 (0.49) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19503759 | 0.76 | EZH2 (0.37) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL24071426 | 0.74 | NOTUM (0.47) | EZH2NOTUMTUBB4ATUBBTUBA3C | |
| SCHEMBL21839787 | 0.74 | NOTUM (0.51) | NOTUMTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL20317447 | 0.73 | EZH2 (0.82) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL20503825 | 0.73 | EED (0.61) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19503754 | 0.72 | EZH2 (0.56) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116655612-A | Synthetic method and application of EZH2 inhibitor | 王亚男 | 2023-08-29 | — | — | CN | disclosed |
| WO-2017184999-A1 | EZH2 INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-10-26 | — | — | WO | disclosed |