Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 9/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL9061405 | 1.00 | LMNA (0.77) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL10801174 | 1.00 | LMNA (0.77) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL475312 | 1.00 | — | — | |
| Acrylic Acid SCHEMBL11340305 | 0.96 | LMNA (0.71) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL29230075 | 0.96 | LMNA (0.71) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL28057938 | 0.96 | LMNA (0.71) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL3361155 | 0.96 | LMNA (0.71) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL11242919 | 0.96 | LMNA (0.71) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL3273148 | 0.96 | LMNA (0.71) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL11126731 | 0.96 | LMNA (0.71) | LMNAALDH1A1FFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9259394-B2 | Partial dip coating of dosage forms for modified release | JOHNSON & JOHNSON CONSUMER INC. (US) | 2016-02-16 | — | — | US | disclosed |
| EP-2509587-A2 | PARTIAL DIP COATING OF DOSAGE FORMS FOR MODIFIED RELEASE | McNeil-PPC, Inc. (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011071877-A2 | PARTIAL DIP COATING OF DOSAGE FORMS FOR MODIFIED RELEASE | MCNEIL-PPC, INC. (US) | 2011-06-16 | — | — | WO | disclosed |
| US-20110135694-A1 | PARTIAL DIP COATING OF DOSAGE FORMS FOR MODIFIED RELEASE | KENVUE BRANDS LLC | 2011-06-09 | — | — | US | disclosed |