SCHEMBL19508147

Cc1cc(C(C)(C)O)cc(S(=O)(=O)NC(=O)Cc2c(C(C)C)cc(F)cc2C(C)CCC(C)c2cc(F)cc(C(C)CCC(C)c3cc(F)cc(C(C)C)c3CC(=O)NS(=O)(=O)c3cccc(C(C)(C)O)c3C)c2CC(=O)NS(=O)(=O)c2ccc(C)c(C(C)(C)O)c2)c1

nearest known ligand 0.38

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	NLRP3	Q96P20	16/20	0.38

▸	SOAT2	O75908	1/20	0.34

▸	MYC	P01106	1/20	0.34

▸	SOAT1	P35610	1/20	0.34

▸	MAP2K3	P46734	1/20	0.34

▸	HTT	P42858	1/20	0.32

▸	EGFR	P00533	1/20	0.32

▸	ERBB2	P04626	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19507302	0.93	NLRP3 (0.42)	NLRP3SOAT2MYCSOAT1MAP2K3
SCHEMBL19507298	0.83	NLRP3 (0.51)	NLRP3SOAT2MYCSOAT1MAP2K3
SCHEMBL19507301	0.83	NLRP3 (0.46)	NLRP3SOAT2MYCSOAT1MAP2K3
SCHEMBL19507899	0.82	NLRP3 (0.52)	NLRP3SOAT2MYCSOAT1MAP2K3
SCHEMBL19507901	0.80	NLRP3 (0.43)	NLRP3SOAT2MYCSOAT1MAP2K3
SCHEMBL19507107	0.77	NLRP3 (0.55)	NLRP3SOAT2MYCSOAT1MAP2K3
SCHEMBL20932982	0.77	NLRP3 (0.55)	NLRP3SOAT2MYCSOAT1MAP2K3
SCHEMBL19507893	0.76	NLRP3 (0.51)	NLRP3SOAT2MYCSOAT1MAP2K3
SCHEMBL30145289	0.76	NLRP3 (0.54)	NLRP3SOAT2MYCSOAT1MAP2K3
SCHEMBL19507897	0.76	NLRP3 (0.54)	NLRP3SOAT2MYCSOAT1MAP2K3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017184604-A1	COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY	IFM THERAPEUTICS, INC (US)	2017-10-26	—	—	WO	disclosed