Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2B | Q14289 | 6/20 | 0.75 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.66 |
| ▸ | IGF1R | P08069 | 14/20 | 0.63 |
| ▸ | MET | P08581 | 14/20 | 0.63 |
| ▸ | KDR | P35968 | 13/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | INSR | P06213 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | FES | P07332 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.60 |
| ▸ | FGR | P09769 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19511666 | 0.94 | PTK2B (0.67) | PTK2BPTK2IGF1RMETKDR | |
| SCHEMBL19511988 | 0.92 | PTK2B (0.77) | PTK2BPTK2IGF1RMETKDR | |
| SCHEMBL198261 | 0.86 | PTK2B (1.00) | PTK2BPTK2IGF1RMETKDR | |
| SCHEMBL19512004 | 0.86 | PTK2B (0.70) | PTK2BPTK2IGF1RMETKDR | |
| SCHEMBL200771 | 0.85 | PTK2B (1.00) | PTK2BPTK2IGF1RMETKDR | |
| SCHEMBL198583 | 0.83 | IGF1R (0.75) | PTK2BIGF1RMETKDRAURKA | |
| SCHEMBL19511441 | 0.81 | PTK2B (0.80) | PTK2BPTK2IGF1RMETKDR | |
| SCHEMBL19511748 | 0.81 | PTK2B (0.78) | PTK2BPTK2IGF1RMETKDR | |
| SCHEMBL13467667 | 0.81 | PTK2B (0.65) | PTK2BPTK2IGF1RMETKDR | |
| SCHEMBL12120994 | 0.80 | IGF1R (0.74) | PTK2BPTK2IGF1RMETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239147-B1 | QUINOLINE DERIVATIVE | ONO PHARMACEUTICAL CO (JP) | 2019-08-28 | — | — | EP | claimed |
| EP-3239147-B1 | QUINOLINE DERIVATIVE | ONO PHARMACEUTICAL CO (JP) | 2019-08-28 | — | — | EP | disclosed |
| US-10208034-B2 | Quinoline derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2019-02-19 | — | — | US | disclosed |
| US-20170349583-A1 | QUINOLINE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-12-07 | — | — | US | disclosed |
| EP-3239147-A1 | QUINOLINE DERIVATIVE | Ono Pharmaceutical Co., Ltd. (JP) | 2017-11-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349583-A1 | QUINOLINE DERIVATIVE | FLT3, AXL, ABL1 | PTK2B 52/4885PTK2 284/4885IGF1R 122/4885 |
| US-10208034-B2 | Quinoline derivative | FLT3, AXL, ABL1 | PTK2B 52/4885PTK2 284/4885IGF1R 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.