Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenidol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 12/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 13/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 12/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 12/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 11/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.97 |
| ▸ | HTR1A | P08908 | 3/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.97 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.97 |
| ▸ | DRD2 | P14416 | 1/20 | 0.97 |
| ▸ | DRD1 | P21728 | 1/20 | 0.97 |
| ▸ | HTR2A | P28223 | 1/20 | 0.97 |
| ▸ | DRD3 | P35462 | 1/20 | 0.97 |
| ▸ | SCN1A | P35498 | 1/20 | 0.97 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.97 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenidol SCHEMBL34469 | 0.98 | CHRM3 (1.00) | CHRM3CHRM4CHRM2CHRM1CHRM5 | |
| SCHEMBL10307554 | 0.97 | CHRM3 (0.97) | CHRM3CHRM4CHRM2CHRM1CHRM5 | |
| Diphenidol SCHEMBL15531902 | 0.95 | CHRM3 (0.94) | CHRM3CHRM4CHRM2CHRM1CHRM5 | |
| Pridinol SCHEMBL363996 | 0.90 | CHRM2 (0.97) | CHRM3CHRM4CHRM2CHRM1CHRM5 | |
| Pridinol SCHEMBL143298 | 0.88 | CHRM2 (1.00) | CHRM3CHRM4CHRM2CHRM1CHRM5 | |
| SCHEMBL7436541 | 0.87 | CHRM3 (0.78) | CHRM3CHRM4CHRM2CHRM1CHRM5 | |
| Pridinol SCHEMBL27496509 | 0.87 | CHRM2 (0.97) | CHRM3CHRM4CHRM2CHRM1CHRM5 | |
| Pridinol SCHEMBL29250415 | 0.87 | CHRM2 (0.97) | CHRM3CHRM4CHRM2CHRM1CHRM5 | |
| Hydrochloric Acid SCHEMBL5501561 | 0.83 | CHRM2 (0.82) | CHRM3CHRM4CHRM2CHRM1CHRM5 | |
| SCHEMBL8967625 | 0.83 | CHRM2 (0.72) | CHRM3CHRM4CHRM2CHRM1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1212 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-220590188-U | Efficient smashing device for production of difenidol hydrochloride | 河南精康制药有限公司 | 2024-03-15 | — | — | CN | claimed |
| CN-109265413-B | Preparation method and refining method of difenidol hydrochloride | 河南精康制药有限公司 | 2022-08-09 | — | — | CN | claimed |
| CN-110551079-B | Preparation method of high-purity difenidol hydrochloride | 株洲千金药业股份有限公司 | 2021-04-06 | — | — | CN | claimed |
| CN-111529502-A | Production process of difenidol hydrochloride tablets | 仁和堂药业有限公司 | 2020-08-14 | — | — | CN | claimed |
| CN-110934842-A | Preparation method of difenidol hydrochloride tablets | 卓和药业集团有限公司 | 2020-03-31 | — | — | CN | claimed |
| CN-110893177-A | Preparation method of difenidol hydrochloride tablets | 仁和堂药业有限公司 | 2020-03-20 | — | — | CN | claimed |
| CN-110638776-A | Preparation process of difenidol hydrochloride tablets | 仁和堂药业有限公司 | 2020-01-03 | — | — | CN | claimed |
| CN-110638775-A | Difenidol hydrochloride tablet and application thereof | 仁和堂药业有限公司 | 2020-01-03 | — | — | CN | claimed |
| CN-110627744-A | Preparation method of difenidol hydrochloride intermediate | 株洲千金药业股份有限公司 | 2019-12-31 | — | — | CN | claimed |
| CN-110632141-A | Method for detecting difenidol hydrochloride by using three-dimensional carbon fiber modified electrode as sensor | 广西科技大学 | 2019-12-31 | — | — | CN | claimed |
| CN-1313762-A | Apomorphine-containing dosage forms for ameliorating male erectile dysfunction | PENTECH PHARMACEUTICALS INC (US) | 2001-09-19 | — | — | CN | claimed |
| US-6291471-B1 | Use of apomorphine for the treatment of organic erectile dysfunction in males | ABB HOLDINGS, INC. | 2001-09-18 | — | — | US | claimed |
| EP-1094799-A1 | APOMORPHINE-CONTAINING DOSAGE FORMS FOR AMELIORATING MALE ERECTILE DYSFUNCTION | PENTECH PHARMACEUTICALS, INC. (US) | 2001-05-02 | — | — | EP | claimed |
| WO-2000054773-A1 | DOPAMINE AGONISTS IN COMBINATION WITH NITRIC OXIDE DONORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2000-09-21 | — | — | WO | claimed |
| US-6121276-A | ORALLY ADMINISTERING DSAGE OF APOMORPHINE TOGETHER WITH ANTIEMETIC PRIOR TO INTERCOURSE; SIDE EFFECT REDUCTION | PENTECH PHARMACEUTICALS, INC. (US) | 2000-09-19 | — | — | US | claimed |
| WO-2000035457-A1 | USE OF APOMORPHINE IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF ORGANIC ERECTILE DYSFUNCTION IN MALES | ABBOTT LABORATORIES (US) | 2000-06-22 | — | — | WO | claimed |
| WO-1999066916-A1 | APOMORPHINE-CONTAINING DOSAGE FORMS FOR AMELIORATING MALE ERECTILE DYSFUNCTION | PENTECH PHARMACEUTICALS, INC. (US) | 1999-12-29 | — | — | WO | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| US-5700410-A | Method of manufacturing wax matrices | NIPPON SHINYAKU CO., LTD. (JP) | 1997-12-23 | — | — | US | claimed |
| EP-0580860-B1 | METHOD OF MANUFACTURING SOLID DISPERSION | NIPPON SHINYAKU CO LTD (JP) | 1997-10-22 | — | — | EP | claimed |