Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.43 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19024881 | 0.87 | PRSS1 (0.48) | PRSS1PRSS2PRSS3ALDH1A1NPC1 | |
| SCHEMBL19024683 | 0.87 | PRSS1 (0.48) | PRSS1PRSS2PRSS3ALDH1A1NPC1 | |
| SCHEMBL19024832 | 0.87 | PRSS1 (0.48) | PRSS1PRSS2PRSS3ALDH1A1NPC1 | |
| SCHEMBL19024950 | 0.87 | PRSS1 (0.48) | PRSS1PRSS2PRSS3ALDH1A1NPC1 | |
| SCHEMBL19024626 | 0.87 | PRSS1 (0.48) | PRSS1PRSS2PRSS3ALDH1A1NPC1 | |
| SCHEMBL19024685 | 0.87 | PRSS1 (0.48) | PRSS1PRSS2PRSS3ALDH1A1NPC1 | |
| SCHEMBL19024912 | 0.87 | PRSS1 (0.48) | PRSS1PRSS2PRSS3ALDH1A1NPC1 | |
| SCHEMBL19024882 | 0.86 | PRSS1 (0.47) | PRSS1PRSS2PRSS3ALDH1A1POLB | |
| SCHEMBL28405618 | 0.85 | ALDH1A1 (0.48) | PRSS1PRSS2PRSS3ALDH1A1ASAH1 | |
| SCHEMBL28405619 | 0.85 | ALDH1A1 (0.48) | PRSS1PRSS2PRSS3ALDH1A1ASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321265-A1 | 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS AND THEIR UTILISATION AS MODULATORS OF TOLL-LIKE RECEPTORS | Gilead Sciences, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |
| EP-3097102-B1 | TOLL-LIKE RECEPTOR MODULATING 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS | GILEAD SCIENCES INC (US) | 2017-10-18 | — | — | EP | disclosed |