Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | TLR4 | O00206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL719480 | 0.92 | HTR2C (0.42) | HTR2CPDE2ACYP1A2TNKSPARP1 | |
| Hydrochloric Acid SCHEMBL30656513 | 0.91 | HTR2C (0.44) | HTR2CPDE2ACYP1A2TNKSPARP1 | |
| SCHEMBL27219395 | 0.88 | HTR2C (0.43) | HTR2CPDE2ACYP1A2 | |
| SCHEMBL19993834 | 0.87 | LMNA (0.42) | LMNAMAPTNPSR1TLR4 | |
| SCHEMBL4917555 | 0.82 | LIG1 (0.40) | LMNAMAPTNPSR1 | |
| SCHEMBL6519821 | 0.76 | SLC6A2 (0.42) | TNKSTNKS2TLR4 | |
| SCHEMBL1616556 | 0.76 | AR (0.40) | TLR4 | |
| SCHEMBL5613574 | 0.75 | SLC6A2 (0.44) | TLR4 | |
| SCHEMBL20267090 | 0.75 | MEN1 (0.39) | LMNA | |
| SCHEMBL1138354 | 0.75 | HTR2C (0.48) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401276-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010098487-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-09-02 | — | — | WO | disclosed |