Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 3/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6142665 | 0.86 | LMNA (0.52) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL19524123 | 0.81 | ERN1 (0.41) | KMT2AALDH1A1CTSLCTSB | |
| SCHEMBL5991889 | 0.81 | LMNA (0.46) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL28356776 | 0.80 | TYR (0.59) | LMNAGAAKMT2AALDH1A1TRIM24 | |
| SCHEMBL19524197 | 0.79 | ERN1 (0.42) | ALDH1A1CTSLCTSBTRIM24TYR | |
| SCHEMBL19524209 | 0.79 | TTR (0.43) | LMNACTSLCTSBCAMK2AMAPT | |
| SCHEMBL5988928 | 0.78 | SCN8A (0.45) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL19524117 | 0.78 | ERN1 (0.50) | KMT2AALDH1A1CTSLCTSBTRIM24 | |
| SCHEMBL1201051 | 0.78 | LMNA (0.75) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL18570705 | 0.77 | SCN8A (0.46) | LMNAGAAKMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2017-11-01 | — | — | EP | disclosed |