Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 9/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | ULK1 | O75385 | 3/20 | 0.39 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | BMX | P51813 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18061447 | 1.00 | LRRK2 (0.41) | LRRK2TBK1JAK2ULK1ULK2 | |
| SCHEMBL15337276 | 1.00 | LRRK2 (0.41) | LRRK2TBK1JAK2ULK1ULK2 | |
| SCHEMBL15337706 | 1.00 | LRRK2 (0.41) | LRRK2TBK1JAK2ULK1ULK2 | |
| SCHEMBL15337510 | 0.90 | ULK1 (0.41) | LRRK2ULK1ULK2EGFRBMX | |
| SCHEMBL15337703 | 0.90 | ULK1 (0.41) | LRRK2ULK1ULK2EGFRBMX | |
| SCHEMBL15337482 | 0.87 | ULK1 (0.40) | TBK1ULK1ULK2EGFRBCL6 | |
| SCHEMBL19527806 | 0.87 | ULK1 (0.40) | TBK1ULK1ULK2EGFRBCL6 | |
| SCHEMBL15337710 | 0.87 | ULK1 (0.40) | TBK1ULK1ULK2EGFRBCL6 | |
| SCHEMBL15337651 | 0.87 | ULK1 (0.40) | TBK1ULK1ULK2EGFRBCL6 | |
| SCHEMBL15337495 | 0.83 | ULK1 (0.42) | ULK1ULK2EGFRBCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2833889-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2017-11-01 | — | — | EP | disclosed |