Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19547155 | 0.86 | JAK2 (0.33) | JAK2NTRK1 | |
| SCHEMBL19547171 | 0.77 | NTRK1 (0.39) | JAK2NTRK1 | |
| SCHEMBL19547145 | 0.77 | JAK2 (0.33) | RIPK1JAK2NTRK1 | |
| SCHEMBL4102082 | 0.69 | RIPK1 (0.37) | RIPK1NTRK1 | |
| SCHEMBL15037563 | 0.68 | RIPK1 (0.36) | RIPK1TRPA1 | |
| SCHEMBL4094951 | 0.66 | JAK2 (0.53) | JAK2NTRK1 | |
| SCHEMBL19547176 | 0.65 | NTRK1 (0.41) | JAK2NTRK1 | |
| SCHEMBL28950160 | 0.65 | NTRK1 (0.41) | JAK2NTRK1 | |
| SCHEMBL4100913 | 0.64 | RIPK1 (0.54) | RIPK1JAK2NTRK1 | |
| SCHEMBL21725645 | 0.64 | RIPK1 (0.54) | RIPK1JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791139-B1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS | Dr Reddys Laboratories Ltd (IN) | 2017-11-08 | — | — | EP | disclosed |