Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 6/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19547181 | 0.91 | NTRK1 (0.49) | NTRK1JAK2FKBP1AHTR2CHTR2A | |
| SCHEMBL19547195 | 0.88 | NTRK1 (0.47) | NTRK1JAK2FKBP1AHTR2CHTR2A | |
| SCHEMBL19547152 | 0.84 | NTRK1 (0.46) | NTRK1JAK2 | |
| SCHEMBL10241011 | 0.75 | CCNT1 (0.52) | HTR2CHTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16310706 | 0.74 | SLC6A2 (0.44) | HTR2CHTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28673947 | 0.74 | NTRK1 (0.46) | NTRK1JAK2HTR2CHTR2ASLC6A2 | |
| SCHEMBL28673945 | 0.74 | NTRK1 (0.46) | NTRK1JAK2HTR2CHTR2ASLC6A2 | |
| SCHEMBL16474297 | 0.73 | SLC6A2 (0.46) | HTR2CHTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28663932 | 0.73 | MAPT (0.52) | NTRK1JAK2 | |
| SCHEMBL28663933 | 0.73 | MAPT (0.52) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791139-B1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS | Dr Reddys Laboratories Ltd (IN) | 2017-11-08 | — | — | EP | disclosed |