Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 17/20 | 0.67 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lomeguatrib SCHEMBL32671218 | 1.00 | MGMT (0.67) | MGMTPIN1LMNACYP1A2CDK1 | |
| SCHEMBL28755928 | 0.85 | MGMT (0.49) | MGMTPIN1LMNACYP1A2CDK1 | |
| SCHEMBL28788534 | 0.81 | MGMT (0.45) | MGMTPIN1LMNACYP1A2CDK1 | |
| Lomeguatrib SCHEMBL29406067 | 0.80 | MGMT (1.00) | MGMTPIN1LMNACYP1A2CDK1 | |
| Lomeguatrib SCHEMBL4621691 | 0.80 | MGMT (1.00) | MGMTPIN1LMNACYP1A2CDK1 | |
| SCHEMBL28756033 | 0.80 | MGMT (0.44) | MGMTPIN1LMNACYP1A2CDK1 | |
| SCHEMBL28755912 | 0.78 | MGMT (0.43) | MGMTPIN1LMNACYP1A2CDK1 | |
| SCHEMBL13160258 | 0.77 | MGMT (0.41) | MGMTPIN1 | |
| SCHEMBL21452794 | 0.73 | PIN1 (0.50) | MGMTPIN1LMNACYP1A2CDK1 | |
| SCHEMBL8618497 | 0.72 | CDK1 (0.44) | MGMTPIN1CDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11992500-B2 | Use of methylation inhibitors for the treatment of autoimmune diseases | RUSH UNIVERSITY MEDICAL CENTER (US) | 2024-05-28 | — | — | US | claimed |
| US-20210128600-A1 | Use of Methylation Inhibitors for the Treatment of Autoimmune Diseases | RUSH UNIVERSITY MEDICAL CENTER (US) | 2021-05-06 | — | — | US | claimed |
| US-11992500-B2 | Use of methylation inhibitors for the treatment of autoimmune diseases | RUSH UNIVERSITY MEDICAL CENTER (US) | 2024-05-28 | — | — | US | disclosed |
| EP-4194548-A1 | GENERATION OF HUMAN PLURIPOTENT STEM CELL DERIVED FUNCTIONAL BETA CELLS SHOWING A GLUCOSE-DEPENDENT MITOCHONDRIAL RESPIRATION AND TWO-PHASE INSULIN SECRETION RESPONSE | Janssen Biotech, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| US-20210128600-A1 | Use of Methylation Inhibitors for the Treatment of Autoimmune Diseases | RUSH UNIVERSITY MEDICAL CENTER (US) | 2021-05-06 | — | — | US | disclosed |
| US-20170321285-A1 | NLRC5 AS A BIOMARKER FOR CANCER PATIENTS AND A TARGET FOR CANCER THERAPY | THE TEXAS A&M UNIVERSITY SYSTEM | 2017-11-09 | — | — | US | disclosed |