Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 19/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555378 | 0.93 | ATF4 (0.66) | ATF4ALDH1A1HPGDTSHR | |
| SCHEMBL19555287 | 0.90 | ATF4 (0.53) | ATF4ALDH1A1HPGDTSHR | |
| SCHEMBL29684544 | 0.89 | ATF4 (0.67) | ATF4ALDH1A1HPGDTSHR | |
| SCHEMBL19555327 | 0.86 | ATF4 (0.71) | ATF4 | |
| SCHEMBL19569497 | 0.85 | ATF4 (0.72) | ATF4 | |
| SCHEMBL19569198 | 0.85 | ATF4 (0.71) | ATF4 | |
| SCHEMBL22656506 | 0.83 | ATF4 (0.56) | ATF4 | |
| SCHEMBL19569488 | 0.83 | ATF4 (0.72) | ATF4 | |
| SCHEMBL19569580 | 0.83 | ATF4 (0.72) | ATF4 | |
| SCHEMBL30024698 | 0.82 | ATF4 (0.79) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704094-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-09 | — | — | EP | disclosed |
| EP-3452448-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |