Sugi Predict

Sugi Predict / Targets / ATF4

ATF4

Cyclic AMP-dependent transcription factor ATF-4 · P18848 · ATF4 on Sugi Atlas →

20,492 patent compounds predicted against ATF4, 9,433 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL655721 SCHEMBL655721 0.72 7/20
SCHEMBL655722 SCHEMBL655722 0.72 7/20
SCHEMBL6386035 SCHEMBL6386035 0.64 7/20
SCHEMBL6386039 SCHEMBL6386039 0.64 7/20
SCHEMBL6386043 SCHEMBL6386043 0.64 7/20
SCHEMBL6920916 SCHEMBL6920916 0.43 7/20
SCHEMBL5260935 SCHEMBL5260935 0.40 7/20
SCHEMBL2978761 SCHEMBL2978761 0.65 6/20
SCHEMBL4954092 SCHEMBL4954092 0.56 6/20
SCHEMBL5123840 SCHEMBL5123840 0.51 6/20
SCHEMBL6462242 SCHEMBL6462242 0.49 6/20
SCHEMBL6462249 SCHEMBL6462249 0.49 6/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL6457541) 0.49 6/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL6457548) 0.49 6/20
Adafenoxate Adafenoxate (SCHEMBL194591) 0.46 6/20
SCHEMBL4335023 SCHEMBL4335023 0.41 6/20
SCHEMBL4335028 SCHEMBL4335028 0.41 6/20
SCHEMBL4336067 SCHEMBL4336067 0.41 6/20
SCHEMBL6333535 SCHEMBL6333535 0.40 6/20
SCHEMBL4033699 SCHEMBL4033699 0.81 5/20

Clinical trials — most relevant to ATF4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity PHASE4COMPLETED
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes PHASE4UNKNOWN
Cancer Chemoprevention by Metformin Hydrochloride Compared to Placebo in Oral Potentially Malignant Lesions PHASE4UNKNOWN
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit PHASE2/PHASE3WITHDRAWN
Decitabine and Venetoclax Treatment as Maintenance Therapy in Patients Post Allograft Stem Cell Transplant PHASE1/PHASE2RECRUITING
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients PHASE1/PHASE2WITHDRAWN
Metformin for Fibromyalgia Symptoms (INFORM Trial) PHASE2RECRUITING
Targeting Endoplasmic Reticulum Stress in Human Hypertension PHASE1/PHASE2RECRUITING
Rapid Antidepressant Effects of Yohimbine in Major Depression PHASE2COMPLETED
Evaluation of the Possible Safety and Efficacy of Dapagliflozin in the Prophylaxis of Doxorubicin-Induced Cardiotoxicity PHASE2RECRUITING
Genomic Effects of Glucocorticoids in Patients With Systemic Lupus Erythematosus EARLY_PHASE1COMPLETED
Quantification of GADD34 Expression in RA nanCOMPLETED
Effect of Protein on Endoplasmic Reticulum Stress nanNOT_YET_RECRUITING
IGF and Other Neurotrophic Factors in Patients With Dementia nanCOMPLETED
Nasturtium (Tropaeolum Majus L) Intake and Biochemical Parameters in Pre-diabetic Subjects in Bogota Colombia nanCOMPLETED
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder. nanCOMPLETED
The NaBu Effect on Menstruation in Women nanRECRUITING
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients nanUNKNOWN
Effect of Branched Chain Amino Acids on Muscle nanCOMPLETED
Nutraceutical Composition Containing Natural Products Derivatives on the Modulation of the Endocrine Neuroimmune Axis nanCOMPLETED
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure nanUNKNOWN
Tecfidera Diffusion Tensor Imaging nanCOMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Calorie Restriction and Brain Function in Mild Cognitive Impairment nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise nanCOMPLETED
Evaluation the Topical Apremilast Nanoformulation in Treatment of Localized Plaque Psoriasis nanNOT_YET_RECRUITING
Multi-level Molecular Profiling of High Acute Stress: a Clinical Study nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a ATF4 binder may also engage these)

ProteinNameSimilarity
Q3ZCH6 — 1.000 Q3ZCH6 →
Q9ES19 — 0.997 Q9ES19 →
Q06507 — 0.996 Q06507 →
Q5NUA6 — 0.992 Q5NUA6 →
O54968 — 0.990 O54968 →
Q6NW59 — 0.990 Q6NW59 →
Q60795 — 0.990 Q60795 →
Q8CDG5 — 0.990 Q8CDG5 →
Q8R5I7 — 0.989 Q8R5I7 →
P79766 — 0.988 P79766 →
O09105 — 0.988 O09105 →
F1QDF8 — 0.988 F1QDF8 →
Q62661 — 0.987 Q62661 →
Q9HD90 — 0.987 Q9HD90 →
Q92172 — 0.987 Q92172 →
Q8IUR6 — 0.987 Q8IUR6 →
Q60430 — 0.986 Q60430 →
P56931 — 0.986 P56931 →
Q23272 — 0.986 Q23272 →
A6H5Y1 — 0.986 A6H5Y1 →
Q90655 — 0.985 Q90655 →
Q5M7N6 — 0.985 Q5M7N6 →
Q68EL6 — 0.985 Q68EL6 →
Q91616 — 0.985 Q91616 →
Q949U2 — 0.985 Q949U2 →
Q32NH9 — 0.985 Q32NH9 →
P10244 — 0.985 P10244 →
Q9JJN2 — 0.985 Q9JJN2 →
P41224 — 0.985 P41224 →
P06537 — 0.985 P06537 →