Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 17/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19577316 | 1.00 | ATF4 (0.47) | ATF4HTR1ADRD2DRD4DRD3 | |
| SCHEMBL19555686 | 0.92 | ATF4 (0.47) | ATF4 | |
| SCHEMBL21066523 | 0.92 | ATF4 (0.47) | ATF4 | |
| SCHEMBL21066508 | 0.91 | ATF4 (0.48) | ATF4 | |
| SCHEMBL19555677 | 0.91 | ATF4 (0.48) | ATF4 | |
| SCHEMBL19555694 | 0.90 | ATF4 (0.46) | ATF4 | |
| SCHEMBL19577513 | 0.90 | ATF4 (0.46) | ATF4 | |
| SCHEMBL30682431 | 0.90 | ATF4 (0.48) | ATF4 | |
| SCHEMBL19555699 | 0.90 | ATF4 (0.48) | ATF4 | |
| SCHEMBL19577311 | 0.90 | ATF4 (0.48) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704089-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-09 | — | — | EP | disclosed |
| EP-3452453-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017193041-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |