Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 10/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19577117 | 1.00 | ATF4 (0.47) | ATF4NPC1ANO1ALDH1A1HTT | |
| SCHEMBL19555680 | 0.93 | ATF4 (0.51) | ATF4ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19577118 | 0.93 | ATF4 (0.51) | ATF4ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL30446203 | 0.91 | ATF4 (0.48) | ATF4HTTP2RX7MEN1KMT2A | |
| SCHEMBL22395076 | 0.91 | ATF4 (0.48) | ATF4HTTP2RX7MEN1KMT2A | |
| SCHEMBL19577518 | 0.91 | ATF4 (0.48) | ATF4HTTP2RX7MEN1KMT2A | |
| SCHEMBL22395175 | 0.91 | ATF4 (0.48) | ATF4HTTP2RX7 | |
| SCHEMBL22395092 | 0.91 | ATF4 (0.48) | ATF4HTTP2RX7 | |
| SCHEMBL19577120 | 0.91 | ATF4 (0.48) | ATF4HTTP2RX7 | |
| SCHEMBL19577310 | 0.91 | ATF4 (0.48) | ATF4HTTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704089-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-09 | — | — | EP | disclosed |
| EP-3452453-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017193041-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |