Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.50 |
| ▸ | GSK3B | P49841 | 12/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19558488 | 0.82 | MAPT (0.47) | MAPTGSK3BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19558478 | 0.82 | MAPT (0.47) | MAPTGSK3BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19558476 | 0.81 | GSK3B (0.46) | MAPTGSK3BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16703268 | 0.80 | GSK3B (0.73) | MAPTGSK3BKDM4DKDM4C | |
| SCHEMBL16710667 | 0.72 | GSK3B (0.70) | MAPTGSK3BKDM4DKDM4C | |
| SCHEMBL16704164 | 0.67 | GSK3B (1.00) | MAPTGSK3B | |
| SCHEMBL16703035 | 0.65 | KDM4C (0.63) | KDM4DKDM4C | |
| SCHEMBL19699514 | 0.65 | BRAF (0.61) | MAPTGSK3BBRAFNPC1RAB9A | |
| SCHEMBL16703056 | 0.64 | GSK3B (0.69) | MAPTGSK3B | |
| SCHEMBL16704172 | 0.64 | GSK3B (0.68) | MAPTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809573-B2 | Substituted pyridine derivatives useful as GSK-3 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-11-07 | — | — | US | disclosed |