Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.47 |
| ▸ | GSK3B | P49841 | 12/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19558459 | 0.82 | MAPT (0.50) | MAPTGSK3BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19558476 | 0.82 | GSK3B (0.46) | MAPTGSK3BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19558488 | 0.81 | MAPT (0.47) | MAPTGSK3BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16703056 | 0.80 | GSK3B (0.69) | MAPTGSK3B | |
| SCHEMBL16704195 | 0.68 | KDM4C (0.47) | MAPTGSK3BGAATHRBNPC1 | |
| SCHEMBL27342084 | 0.64 | TYK2 (0.51) | MAPTGSK3BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16704164 | 0.64 | GSK3B (1.00) | MAPTGSK3B | |
| SCHEMBL16710667 | 0.64 | GSK3B (0.70) | MAPTGSK3BKDM4C | |
| SCHEMBL19699514 | 0.64 | BRAF (0.61) | MAPTGSK3BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16711027 | 0.63 | KDM4C (0.43) | RAB9AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809573-B2 | Substituted pyridine derivatives useful as GSK-3 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-11-07 | — | — | US | disclosed |