Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | FASN | P49327 | 1/20 | 0.60 |
| ▸ | MGLL | Q99685 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 4/20 | 0.58 |
| ▸ | CA1 | P00915 | 4/20 | 0.58 |
| ▸ | CA2 | P00918 | 4/20 | 0.58 |
| ▸ | CA9 | Q16790 | 4/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18753788 | 0.92 | KMT2A (0.74) | KMT2AFASNMGLLCA12CA1 | |
| SCHEMBL20261717 | 0.86 | CA12 (0.73) | KMT2AMGLLCA12CA1CA2 | |
| SCHEMBL2044543 | 0.81 | KMT2A (0.58) | KMT2AFASNMEN1HPGDTSHR | |
| SCHEMBL1663638 | 0.80 | TDP1 (0.73) | KMT2ACA12CA1CA2CA9 | |
| SCHEMBL29067078 | 0.80 | MAPT (0.71) | KMT2AMGLLCA12CA1CA2 | |
| SCHEMBL3004296 | 0.80 | SMN1; SMN2 (0.70) | KMT2AMGLLCA12CA1CA2 | |
| SCHEMBL31267062 | 0.79 | MGLL (0.61) | KMT2AMGLLCA12CA1CA2 | |
| SCHEMBL3001302 | 0.79 | MGLL (0.61) | MGLLCA12CA1CA2CA9 | |
| SCHEMBL13575475 | 0.79 | MGLL (0.61) | MGLLCA12CA1CA2CA9 | |
| SCHEMBL18753791 | 0.79 | CA12 (0.65) | KMT2AMGLLCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3241554-A1 | QUINOLINE-8-SULFONAMIDE DERIVATES HAVING AN ANTICANCER ACTIVITY | Agios Pharmaceuticals, Inc. (US) | 2017-11-08 | — | — | EP | disclosed |