Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 15/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20992495 | 0.85 | ATF4 (0.49) | ATF4ROCK2ROCK1KCNQ3KCNQ2 | |
| SCHEMBL19568416 | 0.85 | ATF4 (0.49) | ATF4ROCK2ROCK1 | |
| SCHEMBL19568409 | 0.85 | ATF4 (0.49) | ATF4EZH2 | |
| SCHEMBL19568388 | 0.84 | ATF4 (0.51) | ATF4EZH2 | |
| SCHEMBL19556040 | 0.83 | ATF4 (0.60) | ATF4ROCK2ROCK1KCNQ3KCNQ2 | |
| SCHEMBL19568686 | 0.81 | ATF4 (0.44) | ATF4 | |
| SCHEMBL19568905 | 0.80 | ATF4 (0.48) | ATF4ROCK2ROCK1KCNQ3KCNQ2 | |
| SCHEMBL19568954 | 0.79 | ATF4 (0.49) | ATF4 | |
| SCHEMBL19569369 | 0.79 | ATF4 (0.52) | ATF4 | |
| SCHEMBL19568274 | 0.78 | ATF4 (0.48) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193063-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |