Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 15/20 | 0.59 |
| ▸ | CD274 | Q9NZQ7 | 15/20 | 0.59 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20324274 | 0.81 | PDCD1 (0.66) | PDCD1CD274TLR9TLR8TLR7 | |
| SCHEMBL19549734 | 0.76 | PDCD1 (0.60) | PDCD1CD274TLR9TLR8TLR7 | |
| SCHEMBL19549722 | 0.75 | PDCD1 (0.82) | PDCD1CD274 | |
| SCHEMBL30504422 | 0.75 | CD274 (0.68) | PDCD1CD274TLR9TLR8TLR7 | |
| SCHEMBL19549776 | 0.74 | CD274 (1.00) | PDCD1CD274TLR9TLR8TLR7 | |
| SCHEMBL19549793 | 0.74 | CD274 (1.00) | PDCD1CD274TLR9TLR8TLR7 | |
| Bromide SCHEMBL437878 | 0.74 | PDCD1 (0.54) | PDCD1CD274TLR9TLR8TLR7 | |
| SCHEMBL14305113 | 0.72 | PDCD1 (0.58) | PDCD1CD274TLR9TLR8TLR7 | |
| SCHEMBL15933482 | 0.72 | PDCD1 (0.54) | PDCD1CD274TLR9TLR8TLR7 | |
| SCHEMBL15933625 | 0.72 | PDCD1 (0.48) | PDCD1CD274TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017192961-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2017-11-09 | — | — | WO | disclosed |