Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 12/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22669460 | 0.91 | ATF4 (0.65) | ATF4ALDH1A1TSHR | |
| SCHEMBL20631578 | 0.84 | ATF4 (0.56) | ATF4ALDH1A1LMNAHPGD | |
| SCHEMBL20631569 | 0.83 | ATF4 (0.55) | ATF4ALDH1A1 | |
| SCHEMBL19569430 | 0.83 | ATF4 (0.80) | ATF4ALDH1A1LMNA | |
| SCHEMBL21390094 | 0.81 | ATF4 (0.58) | ATF4ALDH1A1 | |
| SCHEMBL19569490 | 0.80 | ATF4 (0.57) | ATF4 | |
| SCHEMBL19569260 | 0.80 | ATF4 (0.56) | ATF4 | |
| SCHEMBL19569769 | 0.80 | ATF4 (0.56) | ATF4LMNA | |
| SCHEMBL20631999 | 0.80 | ATF4 (0.50) | ATF4ALDH1A1 | |
| SCHEMBL20631572 | 0.79 | ATF4 (0.55) | ATF4ALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |